Ethyl formate → Ethyl 2-(benzyloxy)-3-oxopropanoate

HRID 869301

Reaktionsgleichung

Reaktionsgleichung von HRID 869301
[H-].[Na+].[CH:3]([O:5][CH2:6][CH3:7])=[O:4].[CH2:8]([O:15][CH2:16][C:17](OCC)=[O:18])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>CCOCC>[CH2:8]([O:15][CH:16]([CH:17]=[O:18])[C:3]([O:5][CH2:6][CH3:7])=[O:4])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

Komponenten

5

Edukt 3

HCID 8025Ethyl formateHCID 24758Sodium hydrideHCID 290299Ethyl 2-(benzyloxy)acetate

Produkt 1

HCID 19903223Ethyl 2-(benzyloxy)-3-oxopropanoate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

To a suspension of sodium hydride (3.3 g, 60% in paraffin oil, 82.5 mmol) in dry ether (100 mL) and dry ethyl formate (5.55 g, 75 mmol) was added ethyl (benzyloxy)acetate (14.57 g, 75 mmol) dropwise with stirring. The resulting mixture solution was then refluxed for 2 h and concentrated to give crude ethyl 2-(benzyloxy)-3-oxopropanoate which was used in the subsequent step without further purification.

Aufarbeitung

  1. temperatureThe resulting mixture solution was then refluxed for 2 h
  2. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-bf3ba2740770454b819b381849387ac0
Quelldatensatz
uspto-grants-2015_03
Patentnummer
US08969364B2

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