Benzaldehyde → HCID 86722234, Verbindung

HRID 869386Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 869386
[C:1]([C:4]1[O:5][C:6]2[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[C:10]([Cl:16])[C:7]=2[C:8]=1[NH2:9])(=[O:3])[CH3:2].[CH:17](=O)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1.[OH-].[Na+].O>CO>[C:1]([C:4]1[O:5][C:6]2[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[C:10]([Cl:16])[C:7]=2[C:8]=1[NH2:9])(=[O:3])[CH:2]=[CH:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

Komponenten

6

Edukt 4

HCID 240BenzaldehydeHCID 962WaterHCID 14798Sodium HydroxideHCID 86722235HCID 86722235, Verbindung

Produkt 1

HCID 86722234HCID 86722234, VerbindungAusbeute 92,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Reaktionsbedingungen

Temperatur
45 °C

Versuchsvorschrift

A mixture of 7G (1.5 g, 6.26 mmol), benzaldehyde (0.863 g, 8.14 mmol, 1.3 eq) and NaOH (1.0 g, 25.04 mmol, 4 eq) in MeOH (20 mL) was stirred at 45° C. for 24 hours. TLC monitored the reaction. After the reaction completed, the reaction mixture was cooled to room temperature and poured into water (20 mL) The yellow solids precipitated out were collected by filtration and dried to give product 8A (1.9 g, 92.6% yield).

Aufarbeitung

  1. customthe reaction
  2. temperaturethe reaction mixture was cooled to room temperature
  3. customprecipitated out
  4. filtrationwere collected by filtration
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-bfb088da04e847ed8265e7dfa61e942b
Quelldatensatz
uspto-grants-2015_03
Patentnummer
US08969373B2

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