1,4-Dioxane → HCID 178488262, Verbindung

HRID 869392Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 869392
[Cl:1][C:2]1[C:7]2[C:8]3[NH:9][CH:10]([C:16]4[N:17]=[C:18]([CH:21]([CH3:23])[CH3:22])[S:19][CH:20]=4)[CH2:11][C:12](=[O:15])[C:13]=3[O:14][C:6]=2[CH:5]=[CH:4][C:3]=1[O:24][CH3:25].O1CCOCC1>O>[OH:15][C:12]1[CH:11]=[C:10]([C:16]2[N:17]=[C:18]([CH:21]([CH3:23])[CH3:22])[S:19][CH:20]=2)[N:9]=[C:8]2[C:7]3[C:2]([Cl:1])=[C:3]([O:24][CH3:25])[CH:4]=[CH:5][C:6]=3[O:14][C:13]=12

Komponenten

4

Edukt 2

HCID 312751,4-DioxaneHCID 86722240HCID 86722240, Verbindung

Produkt 1

HCID 178488262HCID 178488262, VerbindungAusbeute 85,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A mixture of 10B (10.3 g, 27.33 mmol, crude) and FeCl3.6H2O (33.04 g, 164.0 mmol, 6 eq) was added to 1,4-dioxane (300 mL) The mixture was refluxed for 16 hours. TLC monitored the reaction. After the reaction completed, the reaction mixture was cooled to room temperature and poured into water (300 mL), extracted with ethyl acetate and concentrated to give a crude product 10C (8.75 g), which was used for the next step directly.

Aufarbeitung

  1. temperaturewas refluxed for 16 hours
  2. customthe reaction
  3. extractionextracted with ethyl acetate
  4. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-c6d8994519104d73b8fc119851e8f142
Quelldatensatz
uspto-grants-2015_03
Patentnummer
US08969373B2

Notizen zur Reaktion

Wird geladen…