HCID 21914755, Verbindung → HCID 21914786, Verbindung

HRID 869397Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 869397
[C:1]([NH:6][C:7]1[S:8][CH:9]=[C:10]([CH2:12][OH:13])[N:11]=1)(=[O:5])[CH:2]([CH3:4])[CH3:3]>C1COCC1.O=[Mn]=O>[CH:12]([C:10]1[N:11]=[C:7]([NH:6][C:1](=[O:5])[CH:2]([CH3:3])[CH3:4])[S:8][CH:9]=1)=[O:13]

Komponenten

4

Edukt 1

HCID 21914755HCID 21914755, Verbindung

Produkt 1

HCID 21914786HCID 21914786, VerbindungAusbeute 50,4 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 14801Manganese dioxideKatalysatorHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

11C (0.5 g, 2.5 mmol) was dissolved in THF (10 mL). To the solution at room temperature was added activated MnO2 (1.74 g, 20 mmol). The reaction mixture was refluxed overnight, then filtered. The filtrate was concentrated and dried to give a crude product 11D (0.25 g, 50% yield).

Aufarbeitung

  1. temperatureThe reaction mixture was refluxed overnight
  2. filtrationfiltered
  3. concentrationThe filtrate was concentrated
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-9f604a989b0f492380e5dab8441b0aab
Quelldatensatz
uspto-grants-2015_03
Patentnummer
US08969373B2

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