Hydrochloric Acid → HCID 86722251, Verbindung

HRID 869406Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 869406
[C:1]([C:4]1[O:5][C:6]2[CH:13]=[CH:12][C:11]([O:14]C(C)=O)=[C:10]([Br:18])[C:7]=2[C:8]=1[NH2:9])(=[O:3])[CH3:2].C([O-])([O-])=O.[K+].[K+].Cl>CO.O>[C:1]([C:4]1[O:5][C:6]2[CH:13]=[CH:12][C:11]([OH:14])=[C:10]([Br:18])[C:7]=2[C:8]=1[NH2:9])(=[O:3])[CH3:2]

Komponenten

6

Edukt 3

HCID 313Hydrochloric AcidHCID 11430Potassium CarbonateHCID 86722250HCID 86722250, Verbindung

Produkt 1

HCID 86722251HCID 86722251, VerbindungAusbeute 98,7 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

To a mixture of 12E (6.8 g, 0.021 mol) in MeOH (40 mL) and water (20 mL) was added K2CO3 (4.5 g, 0.032 mol) in batches at room temperature. The reaction mixture was stirred at room temperature overnight, then neutralized with diluted hydrochloric acid to pH=6˜7, extracted with ethyl acetate, dried and concentrated to give 12F (5.6 g, 95.1% yield).

Aufarbeitung

  1. extractionextracted with ethyl acetate
  2. customdried
  3. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-70fdf9670d164dcb92cb3c74ae0e0846
Quelldatensatz
uspto-grants-2015_03
Patentnummer
US08969373B2

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