Methanol → HCID 86722258, Verbindung

HRID 869412Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 869412
[C:1]([C:4]1[O:5][C:6]2[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[C:10]([Br:16])[C:7]=2[C:8]=1[NH2:9])(=[O:3])[CH3:2].[CH:17]([C:20]1[S:21][CH:22]=[C:23]([CH:25]=O)[N:24]=1)([CH3:19])[CH3:18].[OH-].[Na+].CO>O>[NH2:9][C:8]1[C:7]2[C:10]([Br:16])=[C:11]([O:14][CH3:15])[CH:12]=[CH:13][C:6]=2[O:5][C:4]=1[C:1](=[O:3])[CH:2]=[CH:25][C:23]1[N:24]=[C:20]([CH:17]([CH3:19])[CH3:18])[S:21][CH:22]=1

Komponenten

6

Edukt 4

HCID 887MethanolHCID 14798Sodium HydroxideHCID 27631922-(Propan-2-yl)-1,3-thiazole-4-carbaldehydeHCID 86722252HCID 86722252, Verbindung

Produkt 1

HCID 86722258HCID 86722258, VerbindungAusbeute 94,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
50 °C

Versuchsvorschrift

A mixture of 12G (2 g, 7 mmol), 2-isopropyl-thiazole-4-carbaldehyde (2.2 g, 14.6 mmol), NaOH (1.5 g) and MeOH (20 mL) was heated to 50° C. and reacted overnight. TLC monitored the reaction. After the reaction completed, the reaction mixture was added dropwise into water. The precipitated solids were collected by filtration to give 15A (2.8 g, 94.4% yield).

Aufarbeitung

  1. customreacted overnight
  2. customthe reaction
  3. filtrationThe precipitated solids were collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-c95180d3aade4f86bd59966307b6144b
Quelldatensatz
uspto-grants-2015_03
Patentnummer
US08969373B2

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