Water → 4-Hydroxyl-9-bromo-2-(2-isopropyl-thiazol-4-yl)-8-methoxy-benzofuro[3,2-b]pyridine

HRID 869414Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 869414
[Br:1][C:2]1[C:7]2[C:8]3[NH:9][CH:10]([C:16]4[N:17]=[C:18]([CH:21]([CH3:23])[CH3:22])[S:19][CH:20]=4)[CH2:11][C:12](=[O:15])[C:13]=3[O:14][C:6]=2[CH:5]=[CH:4][C:3]=1[O:24][CH3:25].O>O1CCOCC1>[OH:15][C:12]1[CH:11]=[C:10]([C:16]2[N:17]=[C:18]([CH:21]([CH3:23])[CH3:22])[S:19][CH:20]=2)[N:9]=[C:8]2[C:7]3[C:2]([Br:1])=[C:3]([O:24][CH3:25])[CH:4]=[CH:5][C:6]=3[O:14][C:13]=12

Komponenten

4

Edukt 2

HCID 962WaterHCID 86722259HCID 86722259, Verbindung

Produkt 1

HCID 1784882614-Hydroxyl-9-bromo-2-(2-isopropyl-thiazol-4-yl)-8-methoxy-benzofuro[3,2-b]pyridineAusbeute 60,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Reaktionsbedingungen

Temperatur
110 °C

Versuchsvorschrift

A mixture of 15B (2.0 g, 4.7 mmol), FeCl3.6H2O (6 g) in 1,4-dioxane (20 mL) was heated to 110° C. and reacted overnight. TLC monitored the reaction. After the reaction completed, the reaction mixture was added dropwise into water. The precipitated solids were collected by filtration to give 15C (1.2 g, 60.2% yield).

Aufarbeitung

  1. customreacted overnight
  2. customthe reaction
  3. filtrationThe precipitated solids were collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-dcd467b0925649f9a1b065fa10fa19fd
Quelldatensatz
uspto-grants-2015_03
Patentnummer
US08969373B2

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