Water → HCID 86722262, Verbindung

HRID 869416Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 869416
[C:1]([C:4]1[O:5][C:6]2[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[C:10]([Br:16])[C:7]=2[C:8]=1[NH2:9])(=[O:3])[CH3:2].[CH:17]([C:19]1[N:20]=[C:21]([NH:24][C:25](=[O:29])[CH:26]([CH3:28])[CH3:27])[S:22][CH:23]=1)=O.[OH-].[Na+].O>C1COCC1>[NH2:9][C:8]1[C:7]2[C:10]([Br:16])=[C:11]([O:14][CH3:15])[CH:12]=[CH:13][C:6]=2[O:5][C:4]=1[C:1](=[O:3])[CH:2]=[CH:17][C:19]1[N:20]=[C:21]([NH:24][C:25](=[O:29])[CH:26]([CH3:27])[CH3:28])[S:22][CH:23]=1

Komponenten

6

Edukt 4

HCID 962WaterHCID 14798Sodium HydroxideHCID 21914786HCID 21914786, VerbindungHCID 86722252HCID 86722252, Verbindung

Produkt 1

HCID 86722262HCID 86722262, VerbindungAusbeute 61,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

A mixture of 12G (2 g, 7 mmol), 11D (2.8 g, 14.5 mmol) in THF (20 mL) was cooled to 0° C. To the mixture was added NaOH (2 g). The reaction mixture was reacted at room temperature overnight. TLC monitored the reaction. After reaction completed, the reaction mixture was added dropwise into water. The precipitated solids were collected by filtration to give 16A (2 g, 61% yield).

Aufarbeitung

  1. customThe reaction mixture was reacted at room temperature overnight
  2. customthe reaction
  3. customAfter reaction
  4. filtrationThe precipitated solids were collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-57a89331ccec49479c9f21fc73896ff6
Quelldatensatz
uspto-grants-2015_03
Patentnummer
US08969373B2

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