Chlorosuccinimide → (2-Bromo-5-chlorothiophen-3-yl)methanol

HRID 870029Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 870029
[Br:1][C:2]1[S:3][CH:4]=[CH:5][C:6]=1[CH2:7][OH:8].[Cl:9]N1C(=O)CCC1=O>C1COCC1.O>[Br:1][C:2]1[S:3][C:4]([Cl:9])=[CH:5][C:6]=1[CH2:7][OH:8]

Komponenten

5

Edukt 2

HCID 31398ChlorosuccinimideHCID 12479010(2-Bromothiophen-3-yl)methanol

Produkt 1

HCID 57900970(2-Bromo-5-chlorothiophen-3-yl)methanol

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a solution of 2-bromo-3-hydroxymethylthiophene from Example 1, Step 1 (13.0 g, 67.3 mmol) in THF (100 mL) and water (10 mL) was added N-chlorosuccinimide (9.88 g, 74.0 mmol) and the mixture was stirred at r.t. for 5 h and concentrated in vacuo. The residue was worked up as above to afford the desired product. The crude product was used directly.

Aufarbeitung

  1. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-127fbcdd4fee4fa897c12acf1cd519ff
Quelldatensatz
uspto-grants-2015_03
Patentnummer
US08969394B2

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