Iodoethane → 2-Bromophenetole

HRID 870466

Reaktionsgleichung

Reaktionsgleichung von HRID 870466
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[OH:8].I[CH2:10][CH3:11].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[O:8][CH2:10][CH3:11]

Komponenten

5

Edukt 3

HCID 6340IodoethaneHCID 72442-BromophenolHCID 11430Potassium Carbonate

Produkt 1

HCID 685002-BromophenetoleAusbeute 95,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

Into a 500-mL round-bottom flask was placed CH3COCH3 (200 mL), 2-bromophenol (10.38 g, 60.00 mmol, 1.00 equiv), iodoethane (28.08 g, 180.04 mmol, 3.00 equiv) and potassium carbonate (33.12 g, 239.64 mmol, 3.99 equiv). The resulting solution was heated to reflux overnight in an oil bath. The solids were filtered out. The filtrate was concentrated under vacuum. The residue was applied onto a silica gel column with ethyl acetate/petroleum ether (1:100). Purification afforded 11.48 g (95%) of 1-bromo-2-ethoxybenzene as a colorless oil.

Aufarbeitung

  1. customInto a 500-mL round-bottom flask was placed
  2. temperatureThe resulting solution was heated
  3. temperatureto reflux overnight in an oil bath
  4. filtrationThe solids were filtered out
  5. concentrationThe filtrate was concentrated under vacuum
  6. customPurification

Quellen und Nachweise

ORD-Eintrag
ord-c41bb86b516b4a38ad60daf8e2dc2224
Quelldatensatz
uspto-grants-2015_03
Patentnummer
US08969557B2

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