Hydrochloric Acid → 806595-48-2

HRID 870572

Reaktionsgleichung

Reaktionsgleichung von HRID 870572
Cl.[CH3:2][O:3][C:4](=[O:11])[CH2:5][CH2:6][CH2:7][CH2:8][C:9]#[N:10].[CH2:12]([O:14]CC)C>CO>[NH:10]=[C:9]([O:14][CH3:12])[CH2:8][CH2:7][CH2:6][CH2:5][C:4]([O:3][CH3:2])=[O:11]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 3283Diethyl Ether2×HCID 554130Methyl 5-cyanopentanoate

Produkt 1

HCID 23189824806595-48-2Ausbeute 83 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

Bubble hydrogen chloride (g) through a 0° C. solution of 5-cyano-pentanoic acid methyl ester (3.0 mL; 1.00 equiv; 22.02 mmoles) in methanol (5 mL), and ethyl ether (10 mL) for 1 hour. Allow the solution to warm to room temperature then add 50 mL ethyl ether, stir vigorously for 15 minutes, then filter and collect the resulting precipitate. Wash the solid with ethyl ether to afford methyl 6-imino-6-methoxy-hexanoate (3.82 g; 83%): 1H NMR (DMSO) δ 1.47-1.62 (m, 4H), 2.31 (t, 2H), 2.59 (t, 2H), 3.56 (s, 3H), 4.03 (s, 3H).

Aufarbeitung

  1. filtrationfilter
  2. customcollect the resulting precipitate
  3. washWash the solid with ethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-c98fa7a79c2c40388b3ab71576959e67
Quelldatensatz
uspto-grants-2015_03
Patentnummer
US08969555B2

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