Risedronate → Phosphate

HRID 871802

Reaktionsgleichung

Reaktionsgleichung von HRID 871802
[CH:1]1[CH:6]=[N:5][CH:4]=[C:3]([CH2:7][C:8]([P:14]([OH:17])([OH:16])=[O:15])([P:10]([OH:13])([OH:12])=[O:11])[OH:9])[CH:2]=1.[P:18]([O-:22])([O-:21])([O-:20])=[O:19].[Ca+2].P([O-])([O-])([O-])=O.[Ca+2].[Ca+2].[OH-].[Na+].C1C=NC=C(CC(P(O)(O)=O)(P(O)(O)=O)O)C=1>O>[CH:1]1[CH:6]=[N:5][CH:4]=[C:3]([CH2:7][C:8]([P:10]([OH:12])([OH:13])=[O:11])([P:14]([OH:17])([OH:16])=[O:15])[OH:9])[CH:2]=1.[P:18]([O-:22])([O-:21])([O-:20])=[O:19]

Komponenten

6

Edukt 3

HCID 5245RisedronateHCID 14798Sodium HydroxideHCID 131732542HCID 131732542, Verbindung

Produkt 2

HCID 1061PhosphateHCID 5245Risedronate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

The risedronate-calcium-phosphate solution and 0.5N sodium hydroxide were simultaneously added to 100 mL water to maintain the pH at 7.00 until all the risedronate had been added. The precipitate was collected by filtration and washed with water. The solid was dried in an oven at 105° C. 3.93 g of calcium complex salt of Risedronate with phosphate were thus obtained.

Aufarbeitung

  1. additionhad been added
  2. filtrationThe precipitate was collected by filtration
  3. washwashed with water
  4. customThe solid was dried in an oven at 105° C

Quellen und Nachweise

ORD-Eintrag
ord-0a522a8974974305a5371efb11cab55e
Quelldatensatz
uspto-grants-2015_03
Patentnummer
US08974801B2

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