Lithium Hydroxide → 2-(Trifluoromethyl)-1,3-thiazole-4-carboxylic acid

HRID 872680

Reaktionsgleichung

Reaktionsgleichung von HRID 872680
[F:1][C:2]([F:14])([F:13])[C:3]1[S:4][CH:5]=[C:6]([C:8]([O:10]CC)=[O:9])[N:7]=1.[OH-].[Li+]>C1COCC1.CO>[F:14][C:2]([F:1])([F:13])[C:3]1[S:4][CH:5]=[C:6]([C:8]([OH:10])=[O:9])[N:7]=1

Komponenten

4

Edukt 2

HCID 3939Lithium HydroxideHCID 20079591Ethyl 2-(trifluoromethyl)-1,3-thiazole-4-carboxylate

Produkt 1

HCID 288755572-(Trifluoromethyl)-1,3-thiazole-4-carboxylic acidAusbeute 93 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 21899815MeOH tetrahydrofuranLösungsmittel

Versuchsvorschrift

Ethyl 2-(trifluoromethyl)thiazole-4-carboxylate (400 mg, 1.176 mmol) was dissolved in THF/methanol mixture (9:1) and 1M lithium hydroxide (3.55 ml, 3.55 mmol) was added slowly. The reaction mixture was stirred at RT for 1 hour, pH was adjusted to 2 and the reaction mixture was extracted three times with ethyl acetate. Ethyl acetate phases were combined, dried and evaporated to dryness. Yield 93%. m/z [197.1+1]

Aufarbeitung

  1. extractionthe reaction mixture was extracted three times with ethyl acetate
  2. customdried
  3. customevaporated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-3cb7e4741a9e40bfbd87db20081dc1ec
Quelldatensatz
uspto-grants-2015_03
Patentnummer
US08975254B2

Verknüpfte Notizen

Wird geladen…