Morpholine → 1-Morpholin-4-yl-[2,6]naphthyridine

HRID 8738Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 8738
Cl[C:2]1[C:11]2[C:6](=[CH:7][N:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][N:3]=1.[NH:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1>>[N:12]1([C:2]2[C:11]3[C:6](=[CH:7][N:8]=[CH:9][CH:10]=3)[CH:5]=[CH:4][N:3]=2)[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1

Komponenten

3

Edukt 2

HCID 8083MorpholineHCID 128847741-Chloro-2,6-naphthyridine

Produkt 1

HCID 219836751-Morpholin-4-yl-[2,6]naphthyridine

Versuchsvorschrift

To 1-chloro-2,6-naphthyridine (164.3 mg, 0.998 mmol) (prepared as described in Van den Haak et al, J. Org. Chem 1982, 47 (9), 1673–7) was added morpholine (15 mL) and the mixture was heated at reflux for 4 h. Removal of the volatile components gave 216.6 mg of 1-morpholin-4-yl-[2,6]naphthyridine as a beige solid.

Aufarbeitung

  1. temperaturethe mixture was heated
  2. temperatureat reflux for 4 h
  3. customRemoval of the volatile components

Quellen und Nachweise

ORD-Eintrag
ord-617f60e42998408eb2d6587c55676ac9
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07091200B2

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