Hydrazine hydrate (1:1) → HCID 178490844, Verbindung
Reaktionsgleichung
[C:1]([C:4]1[CH:8]([C:9]2[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][CH:10]=2)[N:7]([CH2:16][C:17]2[CH:22]=[CH:21][C:20]([O:23][CH3:24])=[CH:19][CH:18]=2)[C:6](=[O:25])[C:5]=1O)(=O)[CH3:2].O.[NH2:28][NH2:29]>>[Cl:15][C:12]1[CH:13]=[CH:14][C:9]([CH:8]2[C:4]3[C:1]([CH3:2])=[N:29][NH:28][C:5]=3[C:6](=[O:25])[N:7]2[CH2:16][C:17]2[CH:22]=[CH:21][C:20]([O:23][CH3:24])=[CH:19][CH:18]=2)=[CH:10][CH:11]=1Komponenten
3
Versuchsvorschrift
The title compound was prepared in analogy to the procedure described in Example 57 using 4-acetyl-5-(4-chlorophenyl)-3-hydroxy-1-(4-methoxybenzyl)-1H-pyrrol-2(5H)-one (Step 71.2) and hydrazine hydrate at 100° C. for 16 hr. tR: 4.75 min (HPLC 1); tR: 1.05 min (LC-MS 2); ESI-MS: 368 [M+H]+ (LC-MS 2); ESI-MS: 366 [M−H]− (LC-MS 2).
Quellen und Nachweise
- ORD-Eintrag
- ord-8f0dab572ef745cca02d1a478cdd5e5f
- Quelldatensatz
- uspto-grants-2015_03
- DOI