Hydrochloric Acid → 2-Phenyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-7-amine hydrochloride

HRID 874341Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 874341
[ClH:1].Cl.[C:3]1([C:9]2[N:10]=[C:11]3[CH:16]=[C:15]([NH2:17])[CH:14]=[CH:13][N:12]3[CH:18]=2)[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[H][H]>[Pt](=O)=O.CO>[ClH:1].[C:3]1([C:9]2[N:10]=[C:11]3[CH2:16][CH:15]([NH2:17])[CH2:14][CH2:13][N:12]3[CH:18]=2)[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1

Komponenten

6

Edukt 3

HCID 313Hydrochloric AcidHCID 117776411HCID 117776411, VerbindungHCID 178418361HCID 178418361, Verbindung2×

Produkt 1

HCID 1055088122-Phenyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-7-amine hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 345198Adams' catalystKatalysator2×HCID 887MethanolLösungsmittel

Versuchsvorschrift

Concentrated hydrochloric acid (0.11 ml) and platinum(IV) dioxide (83 mg) were added to a methanol (183 ml) solution of 2-phenylimidazo[1,2-a]pyridin-7-amine hydrochloride (900 mg), and the obtained mixture was then stirred in a hydrogen atmosphere for 4 hours. Thereafter, platinum(IV) dioxide (83 mg) was added to the reaction solution, and the obtained mixture was further stirred in a hydrogen atmosphere for 14 hours 30 minutes. Thereafter, the reaction solution was filtered with Celite, and was then washed with methanol (15 ml). The filtrate was concentrated under reduced pressure, and diethyl ether (3.6 ml) was then added to the obtained residue to solidify it, so as to obtain the title compound (733 mg) in the form of a gray solid.

Aufarbeitung

  1. filtrationThereafter, the reaction solution was filtered with Celite
  2. washwas then washed with methanol (15 ml)
  3. concentrationThe filtrate was concentrated under reduced pressure, and diethyl ether (3.6 ml)
  4. additionwas then added to the obtained residue

Quellen und Nachweise

ORD-Eintrag
ord-2868c483e453405bb0e7d793090f64df
Quelldatensatz
uspto-grants-2015_03
Patentnummer
US08980888B2

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