Sodium Hydroxide → (2-Fluorobiphenyl-4-yl)methanol

HRID 874485

Reaktionsgleichung

Reaktionsgleichung von HRID 874485
[F:1][C:2]1[CH:7]=[C:6]([CH:8]=[O:9])[CH:5]=[CH:4][C:3]=1[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.[BH4-].[Na+].[OH-].[Na+]>C(O)C>[F:1][C:2]1[CH:7]=[C:6]([CH2:8][OH:9])[CH:5]=[CH:4][C:3]=1[C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1

Komponenten

5

Edukt 3

HCID 14798Sodium HydroxideHCID 27590832-Fluorobiphenyl-4-carboxaldehydeHCID 4311764Sodium borohydride

Produkt 1

HCID 46314883(2-Fluorobiphenyl-4-yl)methanolAusbeute 80 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

2-Fluoro-biphenyl-4-carbaldehyde (1 gm, 5 mmole), NaBH4 were dissolved in ethanol stirred for 2 hrs, NaOH 10% was added, ethanol was evaporated, the reaction mixture was extracted with ethyl acetate, the ethyl acetate extract was dried with Na2SO4 and evaporated to produce white solid (0.8 gm, 80%). H1-NMR INOVA-500 (CDCl3) δ 2.266 (s, 1H), 4.683 (s, 2H), 7.142-7.168 (m, 2H), 7.339-7.442 (m, 4H), 7.519-7.535 (m, 2H).

Aufarbeitung

  1. customethanol was evaporated
  2. extractionthe reaction mixture was extracted with ethyl acetate
  3. extractionthe ethyl acetate extract
  4. dry with materialwas dried with Na2SO4
  5. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-b9955eaf2d694eba973f6d69d19aedf5
Quelldatensatz
uspto-grants-2015_03
Patentnummer
US08980890B2

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