Hydrochloric Acid → HCID 86689368, Verbindung

HRID 875366Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 875366
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([O:11][CH2:12][CH2:13][O:14][CH2:15][CH2:16][O:17][CH2:18][CH2:19][O:20][C:21]2[CH:26]=[CH:25][C:24](/[CH:27]=[CH:28]/[C:29]3[CH:34]=[CH:33][C:32]([N:35](C(OC(C)(C)C)=O)[CH3:36])=[CH:31][CH:30]=3)=[CH:23][CH:22]=2)(=[O:10])=[O:9])=[CH:4][CH:3]=1.[ClH:44]>C(OCC)C>[ClH:44].[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([S:8]([O:11][CH2:12][CH2:13][O:14][CH2:15][CH2:16][O:17][CH2:18][CH2:19][O:20][C:21]2[CH:26]=[CH:25][C:24](/[CH:27]=[CH:28]/[C:29]3[CH:34]=[CH:33][C:32]([NH:35][CH3:36])=[CH:31][CH:30]=3)=[CH:23][CH:22]=2)(=[O:9])=[O:10])=[CH:6][CH:7]=1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 86689367HCID 86689367, Verbindung

Produkt 1

HCID 86689368HCID 86689368, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

200 mg 2-[2-(2-{4-[(E)-2-{4-[(tert-butoxycarbonyl)(methyl)amino]phenyl}-vinyl]phenoxy}ethoxy)ethoxy]ethyl 4-methylbenzenesulfonate (2c) were dissolved in a 2M solution of HCl in diethyl ether. The mixture was stirred at room temperature for 72 h. The solvent was removed under reduced pressure. Diethyl ether was added and the precipitate was collected, washed with diethyl ether and dried under reduced pressure. 160 mg 2e were obtained as light yellow solid.

Aufarbeitung

  1. customThe solvent was removed under reduced pressure
  2. additionDiethyl ether was added
  3. customthe precipitate was collected
  4. washwashed with diethyl ether
  5. customdried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-b9be0a7d2b934ec4b615fdcf08d2ef15
Quelldatensatz
uspto-grants-2015_03
Patentnummer
US08981156B2

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