Acetic Anhydride → N-(4-methyl-5-nitropyridin-2-yl)acetamide

HRID 875381

Reaktionsgleichung

Reaktionsgleichung von HRID 875381
[CH3:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][N:5]=[C:4]([NH2:11])[CH:3]=1.[C:12](OC(=O)C)(=[O:14])[CH3:13]>>[CH3:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][N:5]=[C:4]([NH:11][C:12](=[O:14])[CH3:13])[CH:3]=1

Komponenten

3

Edukt 2

HCID 7918Acetic AnhydrideHCID 2431652-Amino-4-methyl-5-nitropyridine

Produkt 1

HCID 13567013N-(4-methyl-5-nitropyridin-2-yl)acetamideAusbeute 87 %

Reaktionsbedingungen

Temperatur
90 °C

Versuchsvorschrift

A mixture of 4-methyl-5-nitropyridin-2-amine (5 g, 32 mmol) and acetic anhydride (20 mL) was heated at 90° C. for 4 hours. After cooling the solvent was evaporated under vacuum. The concentrated mass was dissolved in toluene and evaporated under vacuum. The resulting solid was triturated with diethyl ether and filtered to afford N-(4-methyl-5-nitropyridin-2-yl) acetamide (5.5 g, 87%).

Aufarbeitung

  1. temperatureAfter cooling the solvent
  2. customwas evaporated under vacuum
  3. dissolutionThe concentrated mass was dissolved in toluene
  4. customevaporated under vacuum
  5. customThe resulting solid was triturated with diethyl ether
  6. filtrationfiltered

Quellen und Nachweise

ORD-Eintrag
ord-d06bd54f5f924e2ebe9150a2b1d7623e
Quelldatensatz
uspto-grants-2015_03
Patentnummer
US08980911B2

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