N-{5-[3-(trifluoromethyl)phenyl]pyridin-3-yl]benzamide → N-{5-[3-(trifluoromethyl)phenyl]piperidin-3-yl}benzamide

HRID 876245Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 876245
[F:1][C:2]([F:25])([F:24])[C:3]1[CH:4]=[C:5]([C:9]2[CH:10]=[C:11]([NH:15][C:16](=[O:23])[C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[CH:12]=[N:13][CH:14]=2)[CH:6]=[CH:7][CH:8]=1>C(O)(=O)C>[F:24][C:2]([F:1])([F:25])[C:3]1[CH:4]=[C:5]([CH:9]2[CH2:14][NH:13][CH2:12][CH:11]([NH:15][C:16]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)=[O:23])[CH2:10]2)[CH:6]=[CH:7][CH:8]=1

Komponenten

3

Edukt 1

HCID 66701292N-{5-[3-(trifluoromethyl)phenyl]pyridin-3-yl]benzamide

Produkt 1

HCID 66701267N-{5-[3-(trifluoromethyl)phenyl]piperidin-3-yl}benzamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

A solution of 840 mg (1.82 mmol) of N-{5-[3-(trifluoromethyl)phenyl]pyridin-3-yl]benzamide in 100 ml of glacial acetic acid was reacted according to General Method 6A. The solution was concentrated under reduced pressure. The product was purified by preparative HPLC (Reprosil C18, water/acetonitrile gradient). Yield: 700 mg

Aufarbeitung

  1. concentrationThe solution was concentrated under reduced pressure
  2. customThe product was purified by preparative HPLC (Reprosil C18, water/acetonitrile gradient)

Quellen und Nachweise

ORD-Eintrag
ord-31b0e3a16f834997a2d8c9fbf8810897
Quelldatensatz
uspto-grants-2015_03
Patentnummer
US08987248B2

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