3-Acetyl-5-bromo-2-hydroxybenzoic acid → 3-Acetyl-2-hydroxybenzoic acid

HRID 876535Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 876535
[C:1]([C:4]1[C:5]([OH:14])=[C:6]([CH:10]=[C:11](Br)[CH:12]=1)[C:7]([OH:9])=[O:8])(=[O:3])[CH3:2]>C(O)C.[Pd]>[C:1]([C:4]1[C:5]([OH:14])=[C:6]([CH:10]=[CH:11][CH:12]=1)[C:7]([OH:9])=[O:8])(=[O:3])[CH3:2]

Komponenten

4

Edukt 1

HCID 110106863-Acetyl-5-bromo-2-hydroxybenzoic acid

Produkt 1

HCID 108992643-Acetyl-2-hydroxybenzoic acidAusbeute 85 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

3-acetyl-5-bromo-2-hydroxybenzoic acid 31 (50 g, 0.19 mol) was dissolved in 250 mL ethanol. After addition of 5.0 g 10% Pd/C the reaction mixture was hydrogenated under 15 atm H2-pressure at room temperature for 6 h. The catalyst was filtered and the solvent was evaporated. The residue was poured into H2O and extracted with CH2Cl2. The combined organic phase was dried and the solvent was removed to give 32 (28 g, 85% yield)

Aufarbeitung

  1. filtrationThe catalyst was filtered
  2. customthe solvent was evaporated
  3. additionThe residue was poured into H2O
  4. extractionextracted with CH2Cl2
  5. customThe combined organic phase was dried
  6. customthe solvent was removed

Quellen und Nachweise

ORD-Eintrag
ord-43d3767f31fd48d9ab13f969cd83fe22
Quelldatensatz
uspto-grants-2015_03
Patentnummer
US08987258B2

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