Sodium Methoxide → N-(5-Methoxy-2-nitrophenyl)-S-methyl-L-cysteine

HRID 877

Reaktionsgleichung

Reaktionsgleichung von HRID 877
F[C:2]1[CH:3]=[CH:4][C:5]([N+:16]([O-:18])=[O:17])=[C:6]([NH:8][C@H:9]([C:13]([OH:15])=[O:14])[CH2:10][S:11][CH3:12])[CH:7]=1.[CH3:19][O-:20].[Na+]>CO>[CH3:19][O:20][C:2]1[CH:3]=[CH:4][C:5]([N+:16]([O-:18])=[O:17])=[C:6]([NH:8][C@H:9]([C:13]([OH:15])=[O:14])[CH2:10][S:11][CH3:12])[CH:7]=1

Komponenten

4

Edukt 2

HCID 10942334Sodium MethoxideHCID 57293179N-(5-Fluoro-2-nitrophenyl)-S-methyl-L-cysteine

Produkt 1

HCID 57147352N-(5-Methoxy-2-nitrophenyl)-S-methyl-L-cysteine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

27 g of N-(5-fluoro-2-nitrophenyl)-S-methyl-L-cysteine (0.1 mol) from Example 1 are dissolved in 150 ml of absolute methanol in a four-necked flask, and 14.4 g of 95% sodium methoxide (0.25 mmol) are added in portions, within the space of 20 minutes and under argon, to this solution while stirring well and while cooling by means of an ice bath. The mixture is then heated to reflux for 2 hours while stirring. TLC monitoring then indicates that the reaction is complete.

Aufarbeitung

  1. temperaturewhile cooling by means of an ice bath
  2. temperatureThe mixture is then heated
  3. temperatureto reflux for 2 hours
  4. stirringwhile stirring

Quellen und Nachweise

ORD-Eintrag
ord-49f2d19dd08c44a6a1032e78dc4359e1
Quelldatensatz
uspto-grants-1998_03
Patentnummer
US05723461

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