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Water → tert-Butyl(4-{[4-(4-chlorophenyl)-1-oxophthalazin-2(1H)-yl]methyl}phenyl)(cyclopentyl)acetate

HRID 877158
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Druckvorschau

Reaktionsgleichung

Reaktionsgleichung von HRID 877158
[H-].[Na+].[Cl:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[C:13](=[O:20])[NH:12][N:11]=2)=[CH:6][CH:5]=1.[C:21]([O:25][C:26](=[O:41])[CH:27]([C:33]1[CH:38]=[CH:37][C:36]([CH2:39]Br)=[CH:35][CH:34]=1)[CH:28]1[CH2:32][CH2:31][CH2:30][CH2:29]1)([CH3:24])([CH3:23])[CH3:22].O>C1COCC1.CN(C=O)C>[C:21]([O:25][C:26](=[O:41])[CH:27]([C:33]1[CH:38]=[CH:37][C:36]([CH2:39][N:12]2[N:11]=[C:10]([C:7]3[CH:6]=[CH:5][C:4]([Cl:3])=[CH:9][CH:8]=3)[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[C:13]2=[O:20])=[CH:35][CH:34]=1)[CH:28]1[CH2:32][CH2:31][CH2:30][CH2:29]1)([CH3:24])([CH3:23])[CH3:22]
KomponentenVersuchsvorschriftAufarbeitungQuellen und NachweiseNotizen zur Reaktion

Komponenten

7

Edukt 4

HCID 962WaterHCID 24758Sodium hydrideHCID 6890844-(4-Chlorophenyl)phthalazin-1-olHCID 15225592tert-Butyl 2-(4-(bromomethyl)phenyl)-2-cyclopentylacetate

Produkt 1

HCID 58136552tert-Butyl(4-{[4-(4-chlorophenyl)-1-oxophthalazin-2(1H)-yl]methyl}phenyl)(cyclopentyl)acetate

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6228DimethylformamideLösungsmittel
HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

At 0° C., 54 mg (2.14 mmol) of sodium hydride were added a little at a time to a solution of 500 mg (1.95 mmol) of 4-(4-chlorophenyl)phthalazin-1(2H)-one [CAS Reg. No. 51334-86-2] in 7.6 ml of THF. After the evolution of gas had ended, 688 mg (1.95 mmol) of tert-butyl[4-(bromomethyl)phenyl](cyclopentyl)acetate, dissolved in 4.5 ml of DMF, were slowly added dropwise at 0° C., and the reaction solution was then stirred at room temperature overnight. Water was then added carefully to the reaction mixture. The reaction mixture was extracted three times with ethyl acetate, and the combined organic phases were washed with saturated sodium chloride solution and dried over sodium sulfate. After filtration, the solvent was removed to dryness under reduced pressure. The crude product obtained was purified by flash chromatography on silica gel (mobile phase: initially cyclohexane/ethyl acetate 3:1, then ethyl acetate). This gave 630 mg (93% pure, 1.11 mmol, 57% of theory) of a colorless solid.

Aufarbeitung

  1. additionwere slowly added dropwise at 0° C.
  2. extractionThe reaction mixture was extracted three times with ethyl acetate
  3. washthe combined organic phases were washed with saturated sodium chloride solution
  4. dry with materialdried over sodium sulfate
  5. filtrationAfter filtration
  6. customthe solvent was removed to dryness under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-d5d043e9a235408a9e959f1e03729cfa
Quelldatensatz
uspto-grants-2015_03
DOI
10.6084/m9.figshare.5104873.v1
Patentnummer
US08987256B2

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