Diisopropylethylamine → HCID 86670803, Verbindung

To a solution of 4-(2-fluorophenyl)-N-(2,2,2-trifluoroethyl)pyridin-3-amine (79 mg, 292 μmol, example 151, intermediate) in CH2Cl2 (2 mL) was added 3-(methylsulfonyl)-5-(trifluoromethyl)benzoic acid (78.4 mg, 292 μmol, example 114, intermediate) and 2-bromo-1-ethylpyridinium tetrafluoroborate (96.1 mg, 351 μmol) and N,N-diisopropylethylamine (75.6 mg, 102 μL, 585 μmol). The reaction mixture was stirred at room temperature for 23 hours. The reaction mixture was concentrated under vacuum. The residue was dissolved in 30 mL 1N aqueous HCl and 30 mL EtOAc and the layers were separated. The aqueous layer was extracted a second time with 30 mL EtOAc. The organic layers were washed with 30 mL 1M aqueous HCl and 30 mL 10% aqueous NaHCO3 and 30 mL brine, dried over MgSO4, filtered and concentrated under vacuum. The residue was purified by silica gel chromatography on a 10 g column using an MPLC (Flashmaster) system eluting with a gradient of n-heptane:EtOAc (100:0 to 0:100). Light yellow solid (37 mg, 24%). MS (ESI): m/z=521.076 [M+H]+.

1. concentrationThe reaction mixture was concentrated under vacuum
2. dissolutionThe residue was dissolved in 30 mL 1N aqueous HCl
3. custom30 mL EtOAc and the layers were separated
4. extractionThe aqueous layer was extracted a second time with 30 mL EtOAc
5. washThe organic layers were washed with 30 mL 1M aqueous HCl and 30 mL 10% aqueous NaHCO3 and 30 mL brine
6. dry with materialdried over MgSO4
7. filtrationfiltered
8. concentrationconcentrated under vacuum
9. customThe residue was purified by silica gel chromatography on a 10 g column
10. washeluting with a gradient of n-heptane:EtOAc (100:0 to 0:100)

ORD-Eintrag

ord-a4448deb762e4bbea4328bbb63cbd542

Quelldatensatz

uspto-grants-2015_03

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US08987307B2