Acetic Acid → 4-Bromo-2-chloro-6-(trifluoromethyl)aniline

HRID 880655

Reaktionsgleichung

Reaktionsgleichung von HRID 880655
[Br:1]N1C(=O)CCC1=O.[Cl:9][C:10]1[CH:16]=[CH:15][CH:14]=[C:13]([C:17]([F:20])([F:19])[F:18])[C:11]=1[NH2:12].C(O)(=O)C>C(#N)C>[Br:1][C:15]1[CH:14]=[C:13]([C:17]([F:19])([F:18])[F:20])[C:11]([NH2:12])=[C:10]([Cl:9])[CH:16]=1

Komponenten

5

Edukt 3

HCID 176Acetic AcidHCID 67184N-bromobutanimideHCID 27563842-Chloro-6-(trifluoromethyl)aniline

Produkt 1

HCID 162179374-Bromo-2-chloro-6-(trifluoromethyl)aniline

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

N-bromo succinimide (910 mg, 5.1 mmol) was added to a solution of 2-chloro-6-(trifluoromethyl)aniline (1.0 g, 5.1 mmol) and acetic acid (3 mL) in acetonitrile (10 mL) at room temperature. The mixture was heated at reflux, with stirring, for 18 h. The reaction mixture was then filtered through Celite and concentrated to give the title compound, which was used in the next step without further purification.

Aufarbeitung

  1. temperatureThe mixture was heated
  2. temperatureat reflux
  3. filtrationThe reaction mixture was then filtered through Celite
  4. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-62cbed9771e744a78af50d42da7422b1
Quelldatensatz
uspto-grants-2015_03
Patentnummer
US08993593B2

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