Acetic Acid → 4-Bromo-2-chloro-6-(trifluoromethyl)aniline

HRID 880657

Reaktionsgleichung

Reaktionsgleichung von HRID 880657
[Br:1]N1C(=O)CCC1=O.[Cl:9][C:10]1[CH:16]=[CH:15][CH:14]=[C:13]([C:17]([F:20])([F:19])[F:18])[C:11]=1[NH2:12].C(O)(=O)C>C(#N)C>[Br:1][C:15]1[CH:14]=[C:13]([C:17]([F:19])([F:18])[F:20])[C:11]([NH2:12])=[C:10]([Cl:9])[CH:16]=1

Komponenten

5

Edukt 3

HCID 176Acetic AcidHCID 67184N-bromobutanimideHCID 27563842-Chloro-6-(trifluoromethyl)aniline

Produkt 1

HCID 162179374-Bromo-2-chloro-6-(trifluoromethyl)aniline

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

N-bromosuccinimide (910 mg, 5.1 mmol) was added to a solution of 2-chloro-6-(trifluoromethyl)aniline (1.0 g, 5.1 mmol) and acetic acid (3 mL) in acetonitrile (10 mL) at room temperature. The mixture was stirred at reflux for 18 h. The reaction mixture was then filtered through Celite and concentrated to give the title compound, which was used in the next step without further purification.

Aufarbeitung

  1. temperatureat reflux for 18 h
  2. filtrationThe reaction mixture was then filtered through Celite
  3. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-e3798e5b36fd4ff7905c6b2482a0d644
Quelldatensatz
uspto-grants-2015_03
Patentnummer
US08993593B2

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