Water → N-(4-bromo-2-chloro-6-methylphenyl)-3,3-dimethylbutanamide

HRID 880662

Reaktionsgleichung

Reaktionsgleichung von HRID 880662
[CH3:1][C:2]([CH3:8])([CH3:7])[CH2:3][C:4](Cl)=[O:5].C(N(CC)CC)C.[Br:16][C:17]1[CH:22]=[C:21]([CH3:23])[C:20]([NH2:24])=[C:19]([Cl:25])[CH:18]=1.O>C(#N)C>[Br:16][C:17]1[CH:22]=[C:21]([CH3:23])[C:20]([NH:24][C:4](=[O:5])[CH2:3][C:2]([CH3:8])([CH3:7])[CH3:1])=[C:19]([Cl:25])[CH:18]=1

Komponenten

6

Edukt 4

HCID 962WaterHCID 8471TriethylamineHCID 815143,3-Dimethylbutanoyl chlorideHCID 27696264-Bromo-2-chloro-6-methylaniline

Produkt 1

HCID 58097339N-(4-bromo-2-chloro-6-methylphenyl)-3,3-dimethylbutanamideAusbeute 100 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

3,3-Dimethylbutanoyl chloride (3.37 g, 3.5 mL, 25 mmol) and triethylamine (2.53 g, 3.5 mL, 25 mmol) were added to a solution of 4-bromo-2-chloro-6-methyl-phenylamine (5.0 g, 25 mmol) in acetonitrile (30 mL). The reaction mixture was stirred at room temperature for 4 hours. Water was added to the mixture, and the precipitate that formed was collected to give the title compound as a powder (7.46 g, 100% yield).

Aufarbeitung

  1. customthe precipitate that formed
  2. customwas collected

Quellen und Nachweise

ORD-Eintrag
ord-ff10b223e2f44ab5acc4cf94b527a2b0
Quelldatensatz
uspto-grants-2015_03
Patentnummer
US08993593B2

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