Acetic Acid → 4-Bromo-2-chloro-6-(trifluoromethyl)aniline

HRID 880663

Reaktionsgleichung

Reaktionsgleichung von HRID 880663
[Br:1]N1C(=O)CCC1=O.[Cl:9][C:10]1[CH:16]=[CH:15][CH:14]=[C:13]([C:17]([F:20])([F:19])[F:18])[C:11]=1[NH2:12].C(O)(=O)C>C(#N)C>[Br:1][C:15]1[CH:14]=[C:13]([C:17]([F:19])([F:18])[F:20])[C:11]([NH2:12])=[C:10]([Cl:9])[CH:16]=1

Komponenten

5

Edukt 3

HCID 176Acetic AcidHCID 67184N-bromobutanimideHCID 27563842-Chloro-6-(trifluoromethyl)aniline

Produkt 1

HCID 162179374-Bromo-2-chloro-6-(trifluoromethyl)aniline

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

N-bromosuccinimide (910 mg, 5.1 mmol) was added at room temperature to a solution of 2-chloro-6-(trifluoromethyl)aniline (1.0 g, 5.1 mmol) and acetic acid (3 mL) in acetonitrile (10 mL). The mixture was stirred at reflux to 18 h. The reaction mixture was then filtered through celite and concentrated to give the title compound, which was used in the next step without further purification.

Aufarbeitung

  1. temperatureat reflux to 18 h
  2. filtrationThe reaction mixture was then filtered through celite and
  3. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-e86951ee787845a19050816024630467
Quelldatensatz
uspto-grants-2015_03
Patentnummer
US08993593B2

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