Water → N-(4-chloro-2-(pyridin-3-yl)thiazol-5-yl)-N,2-dimethyl-3-(methylthio)propanamide

HRID 882002Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 882002
[Cl:1][C:2]1[N:3]=[C:4]([C:15]2[CH:16]=[N:17][CH:18]=[CH:19][CH:20]=2)[S:5][C:6]=1[NH:7][C:8](=[O:14])[CH:9]([CH3:13])[CH2:10][S:11][CH3:12].[C:21](=O)([O-])[O-].[Cs+].[Cs+].IC.O>CN(C)C=O>[Cl:1][C:2]1[N:3]=[C:4]([C:15]2[CH:16]=[N:17][CH:18]=[CH:19][CH:20]=2)[S:5][C:6]=1[N:7]([CH3:21])[C:8](=[O:14])[CH:9]([CH3:13])[CH2:10][S:11][CH3:12]

Komponenten

6

Edukt 4

HCID 962WaterHCID 6328Methyl iodideHCID 10796Cesium carbonateHCID 59580564N-(4-chloro-2-(pyridin-3-yl)thiazol-5-yl)-2-methyl-3-(methylthio)propanamide

Produkt 1

HCID 49765044N-(4-chloro-2-(pyridin-3-yl)thiazol-5-yl)-N,2-dimethyl-3-(methylthio)propanamideAusbeute 89,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel2×

Versuchsvorschrift

To a dry 50 ml round bottom flask equipped with magnetic stirrer, addition funnel, and nitrogen inlet was charged 1.0 g (3.05 mmoles) of N-(4-chloro-2-(pyridin-3-yl)-1,3-thiazol-5-yl)-2-methyl-3-(methylthio)propanamide and 10 mLs of anhydrous N,N-dimethyl formamide. To the resulting solution was then added 1.1 g (3.36 mmoles) of cesium carbonate powder in one portion, followed by the dropwise addition of 0.476 g (3.36 mmoles) of iodomethane in 5 mLs of anhydrous N,N-dimethylformamide. The heterogeneous mixture was stirred at ambient temperature for 12 hours, and then poured into 200 mLs of water and extracted with methylene chloride (3×100 mLs). The combined organic extracts were washed with water (100 mLs), saturated aqueous sodium chloride solution (100 mLs) dried over anhydrous magnesium sulfate, filtered, and concentrated under vacuum on a rotary evaporator. The crude product was purified by silica gel flash chromatography, eluting with a gradient of 100% hexane to 100% ethyl acetate over 20 minutes to yield a yellow oil (0.93 g, 89%): 1H NMR (400 MHz, CDCl3) δ 9.12 (d, J=1.4 Hz, 1H), 8.73 (d, J=3.8 Hz, 1H), 8.34-8.09 (m, 1H), 7.43 (dd, J=7.9, 4.9 Hz, 1H), 3.30 (s, 3H), 3.06-2.70 (m, 2H), 2.49 (d, J=7.4 Hz, 1H), 2.04 (s, 3H), 1.21 (d, J=6.4 Hz, 3H); 13C NMR (101 MHz, DMSO-d6) δ 175.22, 162.37, 151.91, 146.53, 136.46, 134.64, 133.35, 127.98, 124.27, 37.47, 36.71, 36.47, 17.56, 15.44.

Aufarbeitung

  1. customTo a dry 50 ml round bottom flask equipped with magnetic stirrer, addition funnel, and nitrogen inlet
  2. extractionextracted with methylene chloride (3×100 mLs)
  3. washThe combined organic extracts were washed with water (100 mLs), saturated aqueous sodium chloride solution (100 mLs)
  4. dry with materialdried over anhydrous magnesium sulfate
  5. filtrationfiltered
  6. concentrationconcentrated under vacuum on a rotary evaporator
  7. customThe crude product was purified by silica gel flash chromatography
  8. washeluting with a gradient of 100% hexane to 100% ethyl acetate over 20 minutes

Quellen und Nachweise

ORD-Eintrag
ord-0f06096e24484438b7e01c00c0894cb1
Quelldatensatz
uspto-grants-2015_03
Patentnummer
US08993769B2

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