Hydrochloric Acid → HCID 66629751, Verbindung

HRID 882336Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 882336
[ClH:1].[C:2]1([C@@H:8]2[CH2:10][C@H:9]2[NH:11][CH2:12][C:13]2[CH:20]=[CH:19][C:16]([C:17]#[N:18])=[CH:15][CH:14]=2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>CCOCC>[ClH:1].[C:2]1([C@@H:8]2[CH2:10][C@H:9]2[NH:11][CH2:12][C:13]2[CH:14]=[CH:15][C:16]([C:17]#[N:18])=[CH:19][CH:20]=2)[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 46869800HCID 46869800, Verbindung

Produkt 1

HCID 66629751HCID 66629751, VerbindungAusbeute 84,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Reaktionsbedingungen

Temperatur
-78 °C

Versuchsvorschrift

2 M ethereal solution of HCl (0.14 mL, 0.27 mmol) was slowly added to a solution of 4-({[(trans)-2-phenylcyclopropyl]amino}methyl)benzonitrile (67 mg, 0.27 mmol) in dry Et2O (5 mL) cooled at −78° C., and allowed to reach room temperature. After 10 min the white precipitate was allowed to settle and Et2O was decanted, the solid was washed with Et2O (20 mL) and vacuum dried, rendering 65 mg of 4-({[(trans)-2-phenylcyclopropyl]amino}methyl)benzonitrile hydrochloride (white solid, 84% yield).

Aufarbeitung

  1. customto reach room temperature
  2. customEt2O was decanted
  3. washthe solid was washed with Et2O (20 mL) and vacuum
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-9fa84ba054ce4cf3815844a8ffbcbb36
Quelldatensatz
uspto-grants-2015_03
Patentnummer
US08993808B2

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