Hydrazine hydrate (1:1) → ((S)-1-Aminomethyl-butyl)-carbamic acid tert-butyl ester

HRID 882903Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 882903
[C:1]([O:5][C:6](=[O:24])[NH:7][C@H:8]([CH2:12][N:13]1C(=O)C2C(=CC=CC=2)C1=O)[CH2:9][CH2:10][CH3:11])([CH3:4])([CH3:3])[CH3:2].O.NN>CCO.C(Cl)Cl>[C:1]([O:5][C:6](=[O:24])[NH:7][C@H:8]([CH2:12][NH2:13])[CH2:9][CH2:10][CH3:11])([CH3:2])([CH3:3])[CH3:4]

Komponenten

5

Edukt 2

HCID 24654Hydrazine hydrate (1:1)HCID 66917015[(S)-1-(1,3-Dioxo-1,3-dihydro-isoindol-2-ylmethyl)-butyl]-carbamic acid tert-butyl ester

Produkt 1

HCID 86651886((S)-1-Aminomethyl-butyl)-carbamic acid tert-butyl ester

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A mixture of [(S)-1-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-butyl]-carbamic acid tert-butyl ester (2.80 g, 8.42 mmol) and hydrazine monohydrate (3.0 mL, 60.0 mmol) in EtOH (50 mL) and DCM (75 mL) is stirred at RT for 48 h. The precipitated solid is collected by filtration and washed with DCM to afford the crude product as a white solid that is used without further purification.

Aufarbeitung

  1. filtrationThe precipitated solid is collected by filtration
  2. washwashed with DCM

Quellen und Nachweise

ORD-Eintrag
ord-8862f306594549be89bdcbf586b9862e
Quelldatensatz
uspto-grants-2012_08
Patentnummer
US08236808B2

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