Triethylamine → 2-Chloro-1-ethoxy-4-isocyanatobenzene

HRID 882921Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 882921
C(N(CC)CC)C.[CH2:8]([O:10][C:11]1[CH:16]=[CH:15][C:14]([NH2:17])=[CH:13][C:12]=1[Cl:18])[CH3:9].Cl[C:20](Cl)([O:22]C(=O)OC(Cl)(Cl)Cl)Cl>CCOC(C)=O>[CH2:8]([O:10][C:11]1[CH:16]=[CH:15][C:14]([N:17]=[C:20]=[O:22])=[CH:13][C:12]=1[Cl:18])[CH3:9]

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 94429TriphosgeneHCID 127487363-Chloro-4-ethoxyaniline

Produkt 1

HCID 30159672-Chloro-1-ethoxy-4-isocyanatobenzene

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

1-Ethoxy-2-chloro-4-isocyanato-benzene is prepared by addition of triethylamine to a solution of 4-ethoxy-3-chlorophenylamine in EtOAc at 0-5° C. Triphosgene is added and the reaction mixture is slowly heated to reflux over 2 h. The solvent is removed in vacuo and the crude product is filtered through silica to afford the title compound.

Aufarbeitung

  1. temperaturethe reaction mixture is slowly heated
  2. temperatureto reflux over 2 h
  3. customThe solvent is removed in vacuo
  4. filtrationthe crude product is filtered through silica

Quellen und Nachweise

ORD-Eintrag
ord-ae35c798b7ed4080a800857f520a5976
Quelldatensatz
uspto-grants-2012_08
Patentnummer
US08236808B2

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