Hydrochloric Acid → 3-Iodopyridine-4-carboxylic acid

HRID 884936

Reaktionsgleichung

Reaktionsgleichung von HRID 884936
[OH-].[Na+].C[O:4][C:5](=[O:13])[C:6]1[CH:11]=[CH:10][N:9]=[CH:8][C:7]=1[I:12].Cl>O>[I:12][C:7]1[CH:8]=[N:9][CH:10]=[CH:11][C:6]=1[C:5]([OH:13])=[O:4]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 2762504Methyl 3-iodopyridine-4-carboxylate

Produkt 1

HCID 6192753-Iodopyridine-4-carboxylic acidAusbeute 94,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

Water was added to 3.20 g of sodium hydroxide to make 30 ml of aqueous solution in total. To the solution, 5.83 g of 3-iodo-isonicotinic acid methyl ester (U.S. Pat. No. 6,277,871B1, O'Conner et al.) was added. The mixture solution was stirred while heating at 60° C. for three hours. The reaction mixture was cooled in ice, to which concentrated hydrochloric acid was added to adjust pH to 2-3. Precipitates were collected by filtration and dried under reduced pressure to give 5.21 g of 3-iodo-isonicotinic acid.

Aufarbeitung

  1. addition6,277,871B1, O'Conner et al.) was added
  2. additionwas added
  3. customPrecipitates
  4. filtrationwere collected by filtration
  5. customdried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-1d711e2cd668462296c2a56d85cd90c6
Quelldatensatz
uspto-grants-2012_08
Patentnummer
US08242133B2

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