Dimethyl Sulfoxide → 4-Fluoro-3-(2,2,2-trifluoroethoxy)benzaldehyde

Temperatur

65 °C

Methyl 4-fluoro-3-hydroxybenzoate (10 g, 58.8 mmol), 2,2,2-trifluoroethyl trifluoromethanesulfonate (20.4 g, 88 mmol), and Cs2CO3 (51 g, 157 mmol) were dissolved in 200 ml of THF and stirred at 65° C. overnight. Cooled to room temperature and diluted with EtOAc and brine. Layers were separated and the aqueous layer was extracted twice with EtOAc. The organic extracts were combined, dried (Na2SO4), and concentrated to yield 14.82 g (58.8 mmol, 100%). A solution of hydroxybenzoate intermediate (14.82 g, 58.8 mmol) in 150 ml of THF was cooled to 0° C., treated with LiAlH4 (3.95 g, 104 mmol), and allowed to warm to room temperature over 1 hour. Reaction quenched sequentially with 4 ml of water, 4 ml of 1 N NaOH, and 12 ml of water and left to stir for thirty minutes. Reaction was filtered and the filtrate concentrated to a yellow oil (13.33 g, 59 mmol, 100%). A solution of DMSO (10.26 ml, 145 mmol) in 10 ml of dry CH2Cl2 was added dropwise to a solution of oxalyl chloride (33.3 ml, 66.6 mmol) in an additional 100 ml of dry CH2Cl2 and stirred at −78° C. for 20 minutes. A solution of alcohol intermediate (13.33 g, 59 mmol) in 50 ml dry CH2Cl2 was then added and the reaction was stirred at −78° C. for 30 minutes. The reaction was treated with triethylamine (30.8 ml, 221 mmol) and stirred at −78° C. for 30 minutes. The reaction was warmed to 0° C., stirred for 30 minutes, and then allowed to warm to room temperature. Diluted with 1 N HCl and CH2Cl2. The aqueous layer was separated and extracted once with CH2Cl2. The organic layers were combined and washed sequentially with sat'd NaHCO3, 10 vol % bleach in water, and brine. The organic layer was dried (Na2SO4) and concentrated to a yellow solid (12.37 g, 55.7 mmol, 94%).

1. temperatureCooled to room temperature
2. customLayers were separated
3. extractionthe aqueous layer was extracted twice with EtOAc
4. dry with materialdried (Na2SO4)
5. concentrationconcentrated
6. customto yield 14.82 g (58.8 mmol, 100%)
7. temperatureto warm to room temperature over 1 hour
8. customReaction
9. customquenched sequentially with 4 ml of water, 4 ml of 1 N NaOH, and 12 ml of water
10. waitleft
11. stirringto stir for thirty minutes
12. customReaction
13. filtrationwas filtered
14. stirringstirred at −78° C. for 20 minutes
15. stirringthe reaction was stirred at −78° C. for 30 minutes
16. stirringstirred at −78° C. for 30 minutes
17. temperatureThe reaction was warmed to 0° C.
18. stirringstirred for 30 minutes
19. temperatureto warm to room temperature
20. customThe aqueous layer was separated
21. extractionextracted once with CH2Cl2
22. washwashed sequentially with sat'd NaHCO3, 10 vol % bleach in water
23. dry with materialThe organic layer was dried (Na2SO4)

ORD-Eintrag

ord-97827a6852584d148730b6f90a84475b

Quelldatensatz

uspto-grants-2012_08

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US08242150B2