Sodium Methoxide → 5-chloro-4-methoxy-2-methoxymethyl-2H-pyridazin-3-one
Reaktionsgleichung
Cl[C:2]1[C:3](=[O:12])[N:4]([CH2:9][O:10][CH3:11])[N:5]=[CH:6][C:7]=1[Cl:8].[CH3:13][O-:14].[Na+]>O1CCOCC1>[Cl:8][C:7]1[CH:6]=[N:5][N:4]([CH2:9][O:10][CH3:11])[C:3](=[O:12])[C:2]=1[O:14][CH3:13]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
To a stirred solution of 4,5-dichloro-2-methoxymethyl-2H-pyridazin-3one (1.00 g, 4.78 mmol) in 1,4-dioxane (25 mL) at room temperature was added sodium methoxide (271 mg, 5.02 mmol). After 19 h, the reaction was added additional 271 mg of sodium methoxide and was continued to stir for 6 h. The reaction was filtered and the filtrate was concentrated to give 915 mg (93% crude) 5-chloro-4-methoxy-2-methoxymethyl-2H-pyridazin-3-one.
Aufarbeitung
- filtrationThe reaction was filtered
- concentrationthe filtrate was concentrated
Quellen und Nachweise
- ORD-Eintrag
- ord-d50c23316a8a4169a7c6e9ddd96c6c0f
- Quelldatensatz
- uspto-grants-2012_08
- Patentnummer
- US08247414B2
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