Hydrochloric Acid → HCID 57420173, Verbindung

HRID 887062Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 887062
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]1[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][C:18]([O:20][C:21]2[CH:30]=[C:29]3[C:24]([CH2:25][CH2:26][C:27](=[O:31])[NH:28]3)=[CH:23][CH:22]=2)=[O:19])[CH2:11][CH2:10]1.[ClH:32]>ClCCl.C(OCC)C>[ClH:32].[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]1[CH2:10][CH2:11][N:12]([CH2:15][CH2:16][CH2:17][C:18]([O:20][C:21]2[CH:30]=[C:29]3[C:24]([CH2:25][CH2:26][C:27](=[O:31])[NH:28]3)=[CH:23][CH:22]=2)=[O:19])[CH2:13][CH2:14]1

Komponenten

5

Edukt 2

HCID 313Hydrochloric AcidHCID 57420171HCID 57420171, Verbindung

Produkt 1

HCID 57420173HCID 57420173, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 3283Diethyl EtherLösungsmittelHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of the 2-oxo-1,2,3,4-tetrahydroquinolin-7-yl 4-(4-(methoxy-phenyl)piperazin-1-yl)butanoate (19a) (0.1 g) in 2 mL dichloromethane was added 4 mL 2M HCl solution in diethyl ether. The mixture was stirred at room temperature for 30 minutes. The solvent was evaporated, residue was triturated with ether, and solid precipitated was filtered, washed with ether and dried to give 2-oxo-1,2,3,4-tetrahydroquinolin-7-yl 4-(4-(2-methoxyphenyl)piperazin-1-yl)butanoate hydrochloride 20a. The hydrochloride salt 20a gave satisfactory 1H NMR spectral data. White solid, 0.106 g (98%). MS (ESI): m/z=424.1 (M+H+).

Aufarbeitung

  1. customThe solvent was evaporated
  2. customresidue was triturated with ether, and solid
  3. customprecipitated
  4. filtrationwas filtered
  5. washwashed with ether
  6. customdried

Quellen und Nachweise

ORD-Eintrag
ord-b6852d15c935475f87e9f726bcd361e7
Quelldatensatz
uspto-grants-2012_08
Patentnummer
US08247420B2

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