Acetic Anhydride → N-(Isoquinolin-3-yl)acetamide
Reaktionsgleichung
[NH2:1][C:2]1[N:3]=[CH:4][C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[CH:7][CH:6]=2.[CH3:12][C:13](OC(C)=O)=[O:14]>>[CH:4]1[C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH:11]=[C:2]([NH:1][C:13](=[O:14])[CH3:12])[N:3]=1Komponenten
3
Versuchsvorschrift
3-Aminoisoquinoline (495 mg, 3.44 mmol) was stirred in Ac2O (9 mL) at 60° for 16 hours. The mixture was cooled to room temperature and concentrated in vacuo to provide the title compound which was used in the next step without further purification.
Aufarbeitung
- concentrationconcentrated in vacuo
Quellen und Nachweise
- ORD-Eintrag
- ord-fc92afb6bdd2453ab5fb523762a690c5
- Quelldatensatz
- uspto-grants-2012_08
- Patentnummer
- US08247413B2
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