Nitroindoline → 2,3-dihydro-1H-indol-1-amine

HRID 887493Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 887493
[N+:1]([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH2:6][CH2:5]1)([O-])=O>[Pd]>[NH2:1][N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH2:6][CH2:5]1

Komponenten

3

Edukt 1

HCID 21959507Nitroindoline

Produkt 1

HCID 27609322,3-dihydro-1H-indol-1-amine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 23938PalladiumKatalysator

Versuchsvorschrift

Substituted indolines 51 are prepared such as by the procedures described in Scheme 15. Substituted amino-indolines 48 are prepared from the nitroindoline 46 and a ketone in the presence of NaHB(OAc)3 to form the 1-substituted indoline 47. The nitroindoline 47 is hydrogenated, such as with H2 in the presence of a catalyst, such as Pd/C, to yield the amino-indoline 48.

Quellen und Nachweise

ORD-Eintrag
ord-ae879b52ebdb44a2ac27598beae4880e
Quelldatensatz
uspto-grants-2012_08
Patentnummer
US08247430B2

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