Oxalyl chloride → 2-Chloro-4,5-difluorobenzoyl Isocyanate

HRID 887891Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 887891
[Cl:1][C:2]1[CH:10]=[C:9]([F:11])[C:8]([F:12])=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5].C(Cl)(=O)[C:14](Cl)=[O:15]>ClCCl>[Cl:1][C:2]1[CH:10]=[C:9]([F:11])[C:8]([F:12])=[CH:7][C:3]=1[C:4]([N:6]=[C:14]=[O:15])=[O:5]

Komponenten

4

Edukt 2

HCID 65578Oxalyl chlorideHCID 23171512-Chloro-4,5-difluorobenzamide

Produkt 1

HCID 115575832-Chloro-4,5-difluorobenzoyl Isocyanate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

2-Chloro-4,5-difluorobenzamide was dissolved in dichloromethane, mixed with 1.5 eq. of oxalyl chloride and heated to reflux for 16 hours. The reaction mixture was concentrated under high vacuum and employed in stage b without further purification.

Aufarbeitung

  1. temperatureheated
  2. temperatureto reflux for 16 hours
  3. concentrationThe reaction mixture was concentrated under high vacuum
  4. customemployed in stage b without further purification

Quellen und Nachweise

ORD-Eintrag
ord-9117c9352e584eaf92331cbf464dca96
Quelldatensatz
uspto-grants-2012_08
Patentnummer
US08247452B2

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