Ammonia → 4-bromo-1H-indole-2-carboxamide

HRID 888904Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 888904
C(Cl)(=O)C(Cl)=O.[Br:7][C:8]1[CH:16]=[CH:15][CH:14]=[C:13]2[C:9]=1[CH:10]=[C:11]([C:17]([OH:19])=O)[NH:12]2.[NH3:20]>C(Cl)Cl>[Br:7][C:8]1[CH:16]=[CH:15][CH:14]=[C:13]2[C:9]=1[CH:10]=[C:11]([C:17]([NH2:20])=[O:19])[NH:12]2

Komponenten

5

Edukt 3

HCID 222AmmoniaHCID 65578Oxalyl chlorideHCID 40426044-bromo-1H-indole-2-carboxylic acid

Produkt 1

HCID 591512734-bromo-1H-indole-2-carboxamideAusbeute 100 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

Oxalyl chloride (0.9 mL, 10 mmol) was added to a suspension of 4-bromo-1H-indole-2-carboxylic acid (2.1 g, 8.8 mmol) in DCM and the mixture was stirred for 2 h. The solution formed was added drop-wise to a stirring mixture of ammonia (37%, 50 mL) and ice (50 mL). The resulting mixture was allowed to stand for 3 days. The mixture was filtered and the filtrate extracted with EtOAc. The solid from the filtration was dissolved in EtOAc and the organic solutions were combined, dried (MgSO4) and then evaporated to afford the title compound as a brown solid (2.1 g, 100%).

Aufarbeitung

  1. customThe solution formed
  2. additionwas added drop-wise
  3. waitto stand for 3 days
  4. filtrationThe mixture was filtered
  5. extractionthe filtrate extracted with EtOAc
  6. filtrationThe solid from the filtration
  7. dissolutionwas dissolved in EtOAc
  8. dry with materialdried (MgSO4)
  9. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-ce40d6087e0f4d64aa4a233232fbd730
Quelldatensatz
uspto-grants-2012_08
Patentnummer
US08252792B2

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