Hydrochloric Acid → HCID 15219197, Verbindung

HRID 889240Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 889240
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([F:15])[C:10]=1[N+:16]([O-])=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl[Sn]Cl.Cl>CCO>[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([F:15])[C:10]=1[NH2:16])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 24479Stannous ChlorideHCID 578349821-(Benzyloxy)-3-fluoro-2-nitrobenzene

Produkt 1

HCID 15219197HCID 15219197, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of 1-benzyloxy-3-fluoro-2-nitrobenzene (1.32 g, 5.34 mmol), SnCl2 (4.96 g, 26.2 mmol), and 1N HCl (5.5 mL, 5.5 mmol) in EtOH (25 mL) is refluxed for 18 h. The mixture is concentrated and stirred with EtOAc and 1N NaOH solution. Solid NaOH is added until strongly basic. The precipitate is removed by filtration, and the organic phase is separated. It is then dried and concentrated. The residue is purified to give the title compound: MS (M+H)+=218.

Aufarbeitung

  1. temperatureis refluxed for 18 h
  2. concentrationThe mixture is concentrated
  3. additionSolid NaOH is added until strongly basic
  4. customThe precipitate is removed by filtration
  5. customthe organic phase is separated
  6. customIt is then dried
  7. concentrationconcentrated
  8. customThe residue is purified

Quellen und Nachweise

ORD-Eintrag
ord-c9200f16d57a49a9be17e27aa34bd76d
Quelldatensatz
uspto-grants-2012_08
Patentnummer
US08252820B2

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