Ethyl Acetate → 2-(4-Amino-3-fluoro-phenoxy)-2-methyl-propionic acid ethyl ester

HRID 889388Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 889388
[CH2:1]([O:3][C:4](=[O:19])[C:5]([O:8][C:9]1[CH:14]=[CH:13][C:12]([N+:15]([O-])=O)=[C:11]([F:18])[CH:10]=1)([CH3:7])[CH3:6])[CH3:2].[H][H].C(OCC)(=O)C>[Pd].C(O)C>[CH2:1]([O:3][C:4](=[O:19])[C:5]([O:8][C:9]1[CH:14]=[CH:13][C:12]([NH2:15])=[C:11]([F:18])[CH:10]=1)([CH3:7])[CH3:6])[CH3:2]

Komponenten

6

Edukt 3

HCID 8857Ethyl AcetateHCID 671311902-(3-Fluoro-4-nitro-phenoxy)-2-methyl-propionic acid ethyl esterHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 671309762-(4-Amino-3-fluoro-phenoxy)-2-methyl-propionic acid ethyl esterAusbeute 127,5 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

10% Palladium on carbon (200 mg) was added to a solution of 2-(3-fluoro-4-nitro-phenoxy)-2-methyl-propionic acid ethyl ester (1.15 g, 4 mmol) in ethanol (20 ml). The suspension was hydrogenated at a hydrogen gas pressure of 1.7 bar for 8 h at ambient temperature. Ethyl acetate was added (100 ml), the solid was filtered off and the filtrate was brought to dryness under reduced pressure to give the title compound (1.23 g, quant.) which was used in the next step without further purification.

Aufarbeitung

  1. filtrationthe solid was filtered off

Quellen und Nachweise

ORD-Eintrag
ord-29fdff4180c44d04a2fa9ba52ba5d2e7
Quelldatensatz
uspto-grants-2012_08
Patentnummer
US08252826B2

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