Hydrochloric Acid → 6-(4-Chlorophenyl)-1,2,4-triazin-3-one

HRID 889823Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 889823
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH2:9][NH:10][C:11](=[O:14])[NH:12][N:13]=2)=[CH:4][CH:3]=1.[N+](C1C=C(S([O-])(=O)=O)C=CC=1)([O-])=O.[Na+].[OH-].[Na+].Cl>O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:9]=[N:10][C:11](=[O:14])[NH:12][N:13]=2)=[CH:6][CH:7]=1

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 31389Sodium 3-nitrobenzenesulfonateHCID 691185446-(4-Chlorophenyl)-4,5-dihydro-1,2,4-triazin-3-one

Produkt 1

HCID 222487986-(4-Chlorophenyl)-1,2,4-triazin-3-oneAusbeute 83 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A mixture of 3.64 g (17.4 mmol) of 6-(4-chlorophenyl)-4,5-dihydro-1,2,4-triazin-3-one, 4.0 g of sodium m-nitrobenzene sulfonate (17.8 mmol), 6.0 g of 50% sodium hydroxide (75.2 mmol) and 160 mL of water were refluxed overnight. The reaction mixture was cooled, then 1N aqueous HCl was added until the pH was slightly acidic to paper. The product was filtered, washed with water and dried to give 3.0 g of 6-(4-chlorophenyl)-1,2,4-triazin-3-one, which was used without further purification.

Aufarbeitung

  1. temperaturewere refluxed overnight
  2. temperatureThe reaction mixture was cooled
  3. filtrationThe product was filtered
  4. washwashed with water
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-9d533606d6fe4d94b682627da06b647e
Quelldatensatz
uspto-grants-2006_02
Patentnummer
US06995157B2

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