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Sodium Carbonate → 2-Methoxy-3-(4-(2-methylphenoxymethyl)piperidino]methyl-pyrazine

HRID 890069
Notizen
Druckvorschau

Reaktionsgleichung

Reaktionsgleichung von HRID 890069
Cl.[CH3:2][C:3]1[CH:16]=[CH:15][CH:14]=[CH:13][C:4]=1[O:5][CH2:6][CH:7]1[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]1.[CH3:17][O:18][C:19]1[C:20]([CH:25]=O)=[N:21][CH:22]=[CH:23][N:24]=1.C(O[BH-](OC(=O)C)OC(=O)C)(=O)C.[Na+].C(=O)([O-])[O-].[Na+].[Na+]>ClCCl.C(OCC)(=O)C>[CH3:17][O:18][C:19]1[C:20]([CH2:25][N:10]2[CH2:11][CH2:12][CH:7]([CH2:6][O:5][C:4]3[CH:13]=[CH:14][CH:15]=[CH:16][C:3]=3[CH3:2])[CH2:8][CH2:9]2)=[N:21][CH:22]=[CH:23][N:24]=1
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Komponenten

7

Edukt 4

HCID 10340Sodium CarbonateHCID 5049666Sodium triacetoxyborohydrideHCID 158805973-Methoxypyrazine-2-carbaldehydeHCID 172329964-[(2-Methylphenoxy)methyl]piperidine hydrochloride

Produkt 1

HCID 101720282-Methoxy-3-(4-(2-methylphenoxymethyl)piperidino]methyl-pyrazineAusbeute 87,1 %

Reagenzien, Katalysatoren, Lösungsmittel

2
HCID 6344DichloromethaneLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

After suspending 200 mg of 4-(2-methylphenoxymethyl)piperidine hydrochloride in 5 ml of dichloromethane, 137 mg of 3-methoxypyrazine-2-carboxaldehyde [CAS No.63874-90-8] and 264 mg of sodium triacetoxyborohydride were added while stirring, and the stirring was continued overnight at room temperature. Aqueous sodium carbonate solution was added to the reaction mixture and extraction was performed with ethyl acetate. The organic layer was washed with saturated brine and dried over anhydrous magnesium sulfate, and then the solvent was distilled off under reduced pressure. The residue was purified by silica gel column chromatography (solvent: n-hexane/ethyl acetate) to obtain the title compound (236 mg, 87% yield).

Aufarbeitung

  1. washThe organic layer was washed with saturated brine
  2. dry with materialdried over anhydrous magnesium sulfate
  3. distillationthe solvent was distilled off under reduced pressure
  4. customThe residue was purified by silica gel column chromatography (solvent: n-hexane/ethyl acetate)

Quellen und Nachweise

ORD-Eintrag
ord-aaae391673864981a98a53a502303556
Quelldatensatz
uspto-grants-2006_02
DOI
10.6084/m9.figshare.5104873.v1
Patentnummer
US06995144B2

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