2-Acetylbutyrolactone → 3-[1-(3-Mesityl-2-methylanilino)ethylidene]tetrahydro-2-furanone

HRID 890201

Reaktionsgleichung

Reaktionsgleichung von HRID 890201
[C:1]1([CH3:17])[CH:6]=[C:5]([CH3:7])[CH:4]=[C:3]([CH3:8])[C:2]=1[C:9]1[C:10]([CH3:16])=[C:11]([CH:13]=[CH:14][CH:15]=1)[NH2:12].[C:18]([CH:21]1[CH2:26][CH2:25][O:24][C:22]1=[O:23])(=O)[CH3:19]>C(O)C>[C:1]1([CH3:17])[CH:6]=[C:5]([CH3:7])[CH:4]=[C:3]([CH3:8])[C:2]=1[C:9]1[C:10]([CH3:16])=[C:11]([CH:13]=[CH:14][CH:15]=1)[NH:12][C:18](=[C:21]1[CH2:26][CH2:25][O:24][C:22]1=[O:23])[CH3:19]

Komponenten

4

Edukt 2

HCID 106012-AcetylbutyrolactoneHCID 222495383-Mesityl-2-methylaniline

Produkt 1

HCID 695835283-[1-(3-Mesityl-2-methylanilino)ethylidene]tetrahydro-2-furanoneAusbeute 95,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A solution of 3-mesityl-2-methylaniline (5.0 g, 22 mmol) and α-acetyl-γ-butyrolactone (14.2 g, 0.11 mol) in ethanol (100 mL) was heated at reflux for three days. The mixture was evaporated, and the residue was purified by silica gel column chromatography (10% ethyl acetate/hexane), to give the title compound (7.08 g) as white crystals.

Aufarbeitung

  1. temperatureat reflux for three days
  2. customThe mixture was evaporated
  3. customthe residue was purified by silica gel column chromatography (10% ethyl acetate/hexane)

Quellen und Nachweise

ORD-Eintrag
ord-7a6a0f3546714918babc4a68edf0196e
Quelldatensatz
uspto-grants-2006_02
Patentnummer
US06995163B2

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