2-Acetylbutyrolactone → 3-[1-(3-Iodoanilino)ethylidene]tetrahydro-2-furanone

HRID 890202

Reaktionsgleichung

Reaktionsgleichung von HRID 890202
[I:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][CH:8]=1)[NH2:5].[C:9]([CH:12]1[CH2:17][CH2:16][O:15][C:13]1=[O:14])(=O)[CH3:10]>C(O)C>[I:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][CH:8]=1)[NH:5][C:9](=[C:12]1[CH2:17][CH2:16][O:15][C:13]1=[O:14])[CH3:10]

Komponenten

4

Edukt 2

HCID 106012-AcetylbutyrolactoneHCID 122713-Iodoaniline

Produkt 1

HCID 695835373-[1-(3-Iodoanilino)ethylidene]tetrahydro-2-furanoneAusbeute 99,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A solution of 3-iodoaniline (5.0 g, 23 mmol), α-acetyl-γ-butyrolactone (14.6 g, 0.11 mol) in ethanol (100 mL) was heated under reflux for seven days. The mixture was evaporated, and the residue was purified by silica gel column chromatography (10% ethyl acetate/hexane), to give the title compound (7.54 g) as white crystals.

Aufarbeitung

  1. temperatureunder reflux for seven days
  2. customThe mixture was evaporated
  3. customthe residue was purified by silica gel column chromatography (10% ethyl acetate/hexane)

Quellen und Nachweise

ORD-Eintrag
ord-1dc069704bc74b65afd80a761e85316b
Quelldatensatz
uspto-grants-2006_02
Patentnummer
US06995163B2

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