Hydrazine hydrate (1:1) → HCID 135697913, Verbindung

HRID 890693

Reaktionsgleichung

Reaktionsgleichung von HRID 890693
Cl.[CH3:2][O:3][C:4]1[CH:9]=[CH:8][C:7]([CH2:10][C:11]([NH2:13])=[NH:12])=[CH:6][CH:5]=1.O.[NH2:15]N.[C:17]([NH:20][CH:21]([CH3:29])[C:22](=O)[C:23](OCC)=[O:24])(=[O:19])[CH3:18]>>[CH3:2][O:3][C:4]1[CH:5]=[CH:6][C:7]([CH2:10][C:11]2[NH:13][C:23](=[O:24])[C:22]([CH:21]([NH:20][C:17](=[O:19])[CH3:18])[CH3:29])=[N:15][N:12]=2)=[CH:8][CH:9]=1

Komponenten

4

Edukt 3

HCID 24654Hydrazine hydrate (1:1)HCID 12203394(4-Methoxyphenyl)ethanimidamide--hydrogen chloride (1/1)HCID 22245807Ethyl 3-acetamido-2-oxobutanoate

Produkt 1

HCID 135697913HCID 135697913, Verbindung

Versuchsvorschrift

Analogously to Example 7A, 5.1 g (25.4 mmol) of 2-(4-methoxyphenyl)ethanamidine hydrochloride (Example 4A) are reacted with 1.53 g (30.5 mmol) of hydrazine hydrate and 7.14 g (38.1 mol) of ethyl 3-(acetylamino)-2-oxobutanoate (Example 6A) to give N-{1-[3-(4-methoxybenzyl)-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl]ethyl}acetamide.

Quellen und Nachweise

ORD-Eintrag
ord-77ceaf58325a4be4b408ff2d4a5ca463
Quelldatensatz
uspto-grants-2006_02
Patentnummer
US06998402B2

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