Hydrochloric Acid → 7-Methoxynaphthalene-2-carboxylic acid

HRID 890946Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 890946
[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([CH:7]=[CH:8][C:9]([C:13]#N)=[CH:10]2)=[CH:5][CH:4]=1.[OH-:15].[K+].Cl.[OH2:18]>C(O)C>[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([CH:7]=[CH:8][C:9]([C:13]([OH:18])=[O:15])=[CH:10]2)=[CH:5][CH:4]=1

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14797Potassium HydroxideHCID 109541837-Methoxy-2-naphthonitrile

Produkt 1

HCID 222432927-Methoxynaphthalene-2-carboxylic acidAusbeute 98 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
70 °C

Versuchsvorschrift

A solution of 7-methoxy-2-naphthonitrile (501 mg, 2.74 mmol) and KOH (503 mg, 9.0 mmol) in 95% ethanol (5 mL) is heated to reflux for 24 hours. The reaction mixture is allowed to cool, diluted with water and then acidified to pH<2 with concentrated HCl. The resulting precipitate is collected by filtration, washed with water and dried by heating at 70° C. under vacuum to give 7-methoxy-2-naphthoic acid as a white solid (540 mg, 98%). HRMS (FAB) calculated for C12H10O3+H+: 203.0708, found 203.0701.

Aufarbeitung

  1. temperatureto reflux for 24 hours
  2. temperatureto cool
  3. filtrationThe resulting precipitate is collected by filtration
  4. washwashed with water
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-b495e4e4b8e44840997a03d474959a16
Quelldatensatz
uspto-grants-2006_02
Patentnummer
US07001900B2

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