1-Butanol → HCID 21933852, Verbindung

HRID 891423Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 891423
[CH2:1]([OH:5])[CH2:2][CH2:3][CH3:4].C[Si]([N-][Si](C)(C)C)(C)C.[Na+].[F:16][C:17]1[CH:18]=[C:19]([N:24]2[C:29](=[O:30])[C:28](Cl)=[C:27]([Cl:32])[CH:26]=[N:25]2)[CH:20]=[CH:21][C:22]=1[F:23]>C1COCC1>[F:16][C:17]1[CH:18]=[C:19]([N:24]2[C:29](=[O:30])[C:28]([O:5][CH2:1][CH2:2][CH2:3][CH3:4])=[C:27]([Cl:32])[CH:26]=[N:25]2)[CH:20]=[CH:21][C:22]=1[F:23]

Komponenten

5

Edukt 3

HCID 2631-ButanolHCID 2724254Sodium bis(trimethylsilyl)amideHCID 219343084,5-Dichloro-2-(3,4-difluorophenyl)pyridazin-3(2H)-one

Produkt 1

HCID 21933852HCID 21933852, VerbindungAusbeute 79,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel3×

Versuchsvorschrift

To a stirred, room temperature solution of n-butanol (0.81 g, 10.93 mmol, 1.1 equiv.) in THF (20 mL) was slowly added 1.0 M sodium bis(trimethylsilyl)amide in THF (12 mL, 12 mmol, 1.2 equiv.). The reaction mixture was stirred for 0.5 hours, then it was transferred to a solution of 2-(3,4-difluorophenyl)-4,5-dichloro-3(2H)-pyridazinone (2.88 g, 10.4 mmol, 1.0 equiv.) in THF (80 mL). The resulting reaction mixture was stirred for 0.5 hours at room temperature to provide the title compound (2.5 g, 79.4%).

Aufarbeitung

  1. customThe resulting reaction mixture
  2. stirringwas stirred for 0.5 hours at room temperature

Quellen und Nachweise

ORD-Eintrag
ord-45a10491ab8a4933a9bd8b642cc1c1ba
Quelldatensatz
uspto-grants-2006_02
Patentnummer
US07001895B2

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