Glyoxylic Acid → HCID 11259991, Verbindung

HRID 891832

Reaktionsgleichung

Reaktionsgleichung von HRID 891832
[C:1]([OH:5])(=[O:4])[CH:2]=O.[CH2:6]([S:12][S:13][CH2:14][C@H:15]([NH2:19])[C:16]([OH:18])=[O:17])[C@H:7]([NH2:11])[C:8]([OH:10])=[O:9].B([O-])([O-])[O-]>>[C:1]([CH2:2][N:11]([CH2:2][C:1]([OH:5])=[O:4])[C@H:7]([C:8]([OH:10])=[O:9])[CH2:6][S:12][S:13][CH2:14][C@H:15]([N:19]([CH2:15][C:16]([OH:18])=[O:17])[CH2:7][C:8]([OH:10])=[O:9])[C:16]([OH:18])=[O:17])([OH:5])=[O:4]

Komponenten

4

Edukt 3

HCID 760Glyoxylic AcidHCID 26574BorateHCID 67678(-)-Cystine

Produkt 1

HCID 11259991HCID 11259991, Verbindung

Versuchsvorschrift

The alternative route, relying on in solution phase synthesis of an intermediate product starts with addition of a large excess (40 times) of glyoxylic acid to L-cystine in an alkaline borate buffer. The intermediate product was thereafter, after pH manipulations and conductivity adjustment of the reaction mixture, purified with ion exchange chromatography to give N,N,N′,N′-tetrakis (carboxymethyl)-L-cystine.

Aufarbeitung

  1. customThe alternative route, relying on in solution phase synthesis of an intermediate product
  2. customafter pH manipulations and conductivity adjustment of the reaction mixture, purified with ion exchange chromatography

Quellen und Nachweise

ORD-Eintrag
ord-ce089f0ba7b44eafb0e7bc10f2374c60
Quelldatensatz
uspto-grants-2006_02
Patentnummer
US07005071B2

Verknüpfte Notizen

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